Ketamine: stimulating antidepressant treatment?
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چکیده
منابع مشابه
Ketamine: stimulating antidepressant treatment?
SUMMARY The appeal of ketamine - in promptly ameliorating depressive symptoms even in those with non-response - has led to a dramatic increase in its off-label use. Initial promising results await robust corroboration and key questions remain, particularly concerning its long-term administration. It is, therefore, timely to review the opinions of mood disorder experts worldwide pertaining to ke...
متن کاملSustained antidepressant response to ketamine.
Case series outlining the treatment of three patients with ketamine, in which two of the patients had a sustained antidepressant effect to ketamine without the need for maintenance on antidepressants. These two responders have an established diagnosis of bipolar affective disorder with a history of response to electroconvulsive therapy and lithium, both of which have an influence on the seizure...
متن کاملAntidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial.
OBJECTIVE Ketamine, a glutamate N-methyl-d-aspartate (NMDA) receptor antagonist, has shown rapid antidepressant effects, but small study groups and inadequate control conditions in prior studies have precluded a definitive conclusion. The authors evaluated the rapid antidepressant efficacy of ketamine in a large group of patients with treatment-resistant major depression. METHOD This was a tw...
متن کاملCorrection to "Antidepressant Potential of (R)-Ketamine in Rodent Models: Comparison with (S)-Ketamine".
The rapid-acting and long-lasting antidepressant effects of (R,S)-ketamine have recently gained much attention. Although (S)-ketamine has been studied as an active isomer, recent evidence suggests that (R)-ketamine exhibits longer-lasting antidepressant effects than (S)-ketamine in rodents. However, the antidepressant potential of (R)-ketamine has not been fully addressed. In the present study,...
متن کاملIs Metabolism of (R)-Ketamine Essential for the Antidepressant Effects?
154 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact [email protected] International Journal of Neu...
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ژورنال
عنوان ژورنال: BJPsych Open
سال: 2016
ISSN: 2056-4724
DOI: 10.1192/bjpo.bp.116.002923